Here's a neat trick for those of you with a paranoid need to lock down your workstation on a regular basis. Sure, you could hit Ctrl-Alt-Del and click "Lock Workstation" but, that's a multi-keystroke + mouse kind of operation. Hackaback writes with a better and quicker way.

Create a new shortcut anywhere you like on your desktop, and instead of giving the target to an application or document, use this: "rundll32 user32.dll, LockWorkStation". Name it what you will -- "Lock me!" comes to mind -- and you'll have a double-clickable icon that will instantly lock up your valuable data.